Detalhe da pesquisa
1.
Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs.
PLoS Biol
; 19(7): e3001355, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34319985
2.
Morphological profiling of tubercle bacilli identifies drug pathways of action.
Proc Natl Acad Sci U S A
; 117(31): 18744-18753, 2020 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32680963
3.
A Novel Oral GyrB/ParE Dual Binding Inhibitor Effective against Multidrug-Resistant Neisseria gonorrhoeae and Other High-Threat Pathogens.
Antimicrob Agents Chemother
; 66(9): e0041422, 2022 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35972242
4.
Structural basis of DSF recognition by its receptor RpfR and its regulatory interaction with the DSF synthase RpfF.
PLoS Biol
; 17(2): e3000123, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30716063
5.
Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance.
Angew Chem Int Ed Engl
; 61(45): e202211498, 2022 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36222275
6.
Metagenome-Guided Analogue Synthesis Yields Improved Gram-Negative-Active Albicidin- and Cystobactamid-Type Antibiotics.
Angew Chem Int Ed Engl
; 60(41): 22172-22177, 2021 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34355488
7.
Machine Learning Platform to Discover Novel Growth Inhibitors of Neisseria gonorrhoeae.
Pharm Res
; 37(7): 141, 2020 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32661900
8.
Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis.
Proc Natl Acad Sci U S A
; 114(17): 4495-4500, 2017 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28396391
9.
Non-classical transpeptidases yield insight into new antibacterials.
Nat Chem Biol
; 13(1): 54-61, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27820797
10.
The Natural Product Eugenol Is an Inhibitor of the Ebola Virus In Vitro.
Pharm Res
; 36(7): 104, 2019 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31101988
11.
Synthesis and biological evaluation of solithromycin analogs against multidrug resistant pathogens.
Bioorg Med Chem Lett
; 29(11): 1386-1389, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30962084
12.
Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agent.
Bioorg Med Chem Lett
; 29(4): 601-606, 2019 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30600207
13.
Novel Pyrimidines as Antitubercular Agents.
Antimicrob Agents Chemother
; 62(3)2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29311070
14.
Discovery of MRSA active antibiotics using primary sequence from the human microbiome.
Nat Chem Biol
; 12(12): 1004-1006, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27748750
15.
Comparing and Validating Machine Learning Models for Mycobacterium tuberculosis Drug Discovery.
Mol Pharm
; 15(10): 4346-4360, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29672063
16.
Naïve Bayesian Models for Vero Cell Cytotoxicity.
Pharm Res
; 35(9): 170, 2018 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-29959603
17.
Antimicrobials Inspired by Nonribosomal Peptide Synthetase Gene Clusters.
J Am Chem Soc
; 139(4): 1404-1407, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28055186
18.
Mycobacterium abscessus l,d-Transpeptidases Are Susceptible to Inactivation by Carbapenems and Cephalosporins but Not Penicillins.
Antimicrob Agents Chemother
; 61(10)2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28760902
19.
Correction to "Comparing and Validating Machine Learning Models for Mycobacterium tuberculosis Drug Discovery".
Mol Pharm
; 18(7): 2833, 2021 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34137624
20.
Predicting Mouse Liver Microsomal Stability with "Pruned" Machine Learning Models and Public Data.
Pharm Res
; 33(2): 433-49, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26415647